Wilopres Plus 50 mg/12.5 mg/Wilopres Plus 100 mg/25 mg

Per 50 mg/12.5 mg FC tab Losartan K 50 mg, hydrochlorothiazide 12.5 mg. Per 100 mg/25 mg FC tab Losartan K 100 mg, hydrochlorothiazide 25 mg

HTN. Reduce risk of stroke in patients w/ HTN & left ventricular hypertrophy.

HTN 50 mg/12.5 mg once daily, can be increased after 3 wk of therapy to a max of 100 mg/25 mg once daily as needed to control BP. Hypertensive patient w/ left ventricular hypertrophy Initially 50 mg/12.5 mg once daily, may be increased to 100 mg/25 mg once daily if additional BP reduction is needed.

May be taken with or without food.

Hypersensitivity. Anuria. Diabetic patients who are taking aliskiren.

Hypotension in vol- or salt-depleted patients; do not use as initial therapy in patients w/ intravascular vol depletion. Electrolyte & metabolic effects. Monitor serum electrolytes periodically. Risk of acute renal failure in patients w/ renal artery stenosis, CKD, severe CHF, or vol-depletion. Impaired renal function. Discontinue drug immediately when pregnancy is detected. Lactation. Hydrochlorothiazide: Acute myopia & secondary angle-closure glaucoma. May exacerbate or activate SLE. Increased risk of non-melanoma skin cancer (basal cell carcinoma & squamous cell carcinoma). Limit exposure to sunlight & UV rays.

Increase in serum lithium conc. Deterioration of renal function, including possible acute renal failure w/ NSAIDs including selective COX-2 inhibitors in patients who are elderly, vol-depleted (including those on diuretic therapy), or w/ compromised renal function. Increased risk of hypotension, syncope, hyperkalemia, & changes in renal function (including acute renal failure) w/ ARBs, ACE inhibitors, or aliskiren. Concomitant use w/ antidiabetic drugs. Additive effect or potentiation w/ other antihypertensive drugs. Losartan: May result in hyperkalemia w/ agents increasing serum K. NSAIDs including COX-2 inhibitors may attenuate antihypertensive effect. Hydrochlorothiazide: Impaired absorption w/ cholestyramine & colestipol. Potentiation of orthostatic hypotension w/ alcohol, barbiturates, or narcotics. Possible increased responsiveness to skeletal muscle relaxants, nondepolarizing (eg, tubocurarine). May intensify electrolyte depletion, particularly hypokalemia w/ corticosteroids, ACTH, or glycyrrhizin. Decreased response to pressor amines eg, norepinephrine.

Angiotensin II Antagonists / Diuretics

C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.

Rx